Djokovic, who also reached the Monte Carlo Masters final in 2009 and 2012, had far too much for Fognini, playing in his first Masters series final, and booked his place in the championship match in just 52 minutes.
Djokovic, who has branded Nadal "the ultimate challenge on clay", will hope to improve on his previous Monte Carlo finals against Nadal. He was beaten 6-3 6-1 in the final last year and in three sets in 2009.
Italian showman Fognini played some crowd-pleasing winners against Djokovic but was no match for the ruthless Serb who was in no mood to mess around on the centre court.
The 32nd-ranked Italian, who has enjoyed a huge support this week at a stadium located just kilometres away from his home, offered little fight and was booed off court after only 50 minutes by the restless crowd.
Djokovic seems to have put his injury problem - he twisted his ankle on Davis Cup duty with Serbia a fortnight ago - behind him.
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