British number two Watson got back to winning ways with a first round win over Melinda Czink on Tuesday but fell 6-4 6-3 to Alla Kudryavtseva, a player ranked 172nd in the world.
It was only Watson’s third competitive outing since recovering from a bout of glandular fever. The Guernsey player only returned from a four-month absence from the WTA Tour at Roland Garros two weeks ago.
But her Russian opponent clinched a solitary break in the opening set on the Ann Jones Centre Court before four further breaks in the second saw her complete victory in 71 minutes.
Robson faced an awkward second round match against former Aegon Classic finalist Daniela Hantuchova and lost 6-4 6-3.
The British number one, seeded seventh, had a bye in the first round but had no answer to the Slovak, struggling with a first serve percentage under 50 per cent and being broken twice in the first set and suffering the only break of the second,
Their Fed Cup team-mate Johanna Konta also lost, going down 6-4 6-1 to Frenchwoman Kristina Mladenovic.
There was another upset as second seed Ekaterina Makarova lost to New Zealander Marina Erakovic 7-6(6) 3-6 6-0.
Top seeded Belgian Kirsten Flipkens suffered a scare but eventually beat Croatian qualifier Ajla Tomljanovic 4-6 6-4 7-5 in the day's final match.
WTA Birmingham - Round 2 results
1-Kirsten Flipkens (Belgium) beat Ajla Tomljanovic (Croatia) 4-6 6-4 7-5
Marina Erakovic (New Zealand) beat 2-Ekaterina Makarova (Russia) 7-6(6) 3-6 6-0
3-Sorana Cirstea (Romania) beat Tsvetana Pironkova (Bulgaria) 6-4 6-4
5-Sabine Lisicki (Germany) beat Kristyna Pliskova (Czech Republic) 6-4 6-2
Daniela Hantuchova (Slovakia) beat 7-Laura Robson (Britain) 6-3 6-4
Mirjana Lucic-Baroni (Croatia) beat 9-Yanina Wickmayer (Belgium) 6-4 6-0
15-Francesca Schiavone (Italy) beat Nadiya Kichenok (Ukraine) 7-6(4) 6-2
16-Magdalena Rybarikova (Slovakia) beat Mathilde Johansson (France) 7-5 6-7(4) 6-4
12-Kristina Mladenovic (France) beat Johanna Konta (Britain) 6-4 6-1
13-Bojana Jovanovski (Serbia) beat Andrea Hlavackova (Czech Republic) 4-6 6-1 6-4
Alla Kudryavtseva (Russia) beat 14-Heather Watson (Britain) 6-4 6-3
Maria Sanchez (U.S.) beat Alison Van Uytvanck (Belgium) 7-6(3) 6-3
WTA Nuremberg - Round 2 results
1-Jelena Jankovic (Serbia) beat Johanna Larsson (Sweden) 6-2 6-0
Galina Voskoboeva (Kazakhstan) beat 3-Alize Cornet (France) 2-6 6-3 6-3
5-Lucie Safarova (Czech Republic) beat Maria Teresa Torro (Spain) 6-4 6-2
6-Lourdes Dominguez Lino (Spain) beat Mandy Minella (Luxembourg) 6-1 6-4
7-Simona Halep (Romania) beat Estrella Cabeza Candela (Spain) 6-2 6-1
8-Annika Beck (Germany) beat Karin Knapp (Italy) 6-4 6-2
Polona Hercog (Slovenia) beat Julia Cohen (U.S.) 6-3 6-3
Andrea Petkovic (Germany) beat 4-Julia Goerges (Germany) 6-1 7-5
Round 1 results
1-Jelena Jankovic (Serbia) beat Arantxa Rus (Netherlands) 6-4 6-2
Polona Hercog (Slovenia) beat 2-Klara Zakopalova (Czech Republic) 6-3 4-6 6-1
7-Simona Halep (Romania) beat Grace Min (U.S.) 6-0 7-5
Estrella Cabeza Candela (Spain) beat Tereza Martincova (Czech Republic) 6-2 6-3
- Sports & Recreation
- Alla Kudryavtseva
- Daniela Hantuchova
- Czech Republic
- Johanna Konta