Lu Yen-hsun, a Taiwanese chicken farmer's son who goes by the name of "Randy", clipped Murray's wings in 2008 but it would be a far greater scalp if he caused an upset on No. 1 Court.
"I know quite a lot about him," US Open champion Murray said after beating Benjamin Becker in the first round.
"I lost to him in the Olympics in 2008 in Beijing. It was a very tough loss for me. I learnt a lot from that match.
"I think I've only played him once more. I played him earlier this year in Indian Wells... He's made the quarters before; he's beaten (Andy) Roddick here; he plays well on grass. So I'll need to be ready."
Seven-times champion Roger Federer is back on his favourite Centre Court to face Sergiy Stakhovsky of Ukraine after an imperious first-round romp against Romania's Victor Hanescu.
In the women's draw, Maria Sharapova plays Portugal's Michelle Larcher De Brito in what will be a noisy encounter on No. 2 Court between two of the game's great grunters.
Second-seeded Belarussian Victoria Azarenka opens proceedings on Centre Court against Italy's Flavia Pennetta.
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