The fifth-seeded Pavlyuchenkova overcame 13 double faults and outlasted her German counterpart as she rallied dangerously in the third set to come back from 0-5 and win the next four consecutive games.
But the 21-year-old Russian countered by breaking the world number six Kerber for the fifth time, and used the momentum to wrap up the match in just under two hours.
Pavlyuchenkova, whose victory marks her first WTA title of 2013, has now beaten Kerber both times the pair have come head-to-head, having played once before at Brisbane in January.
She won the Monterrey Open in both 2010 and 2011 before sitting out the event in 2012 to play in Dubai.
- Sports & Recreation