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Dominic Thiem will head to the French Open on the back of six consecutive defeats after he was knocked out of the Geneva Open by Marco Cecchinato.
Thiem missed the second half of last season due to a wrist injury and has won only one set in six matches since returning at an ATP Challenger Tour event in Marbella in March.
The 2020 US Open champion's latest loss came at the hands of Marco Cecchinato, who prevailed 6-3 6-4 to reach the second round on Monday.
A two-time runner-up at Roland Garros, Austrian Thiem will travel to Paris struggling to return to form following such a long absence.
Cecchinato had lost all 11 matches this year, but has won three in Geneva without losing a set after coming through qualifying and will now face Kamil Majchrzak.
Federico Delbonis, the seventh seed, beat Ricardas Berankis 6-4 6-4, while French duo Richard Gasquet and Benoit Paire made it through to the last 16 along with Ilya Ivashka.
There will be no fairytale win for Jo-Wilfried Tsonga, who will retire after the French Open, at the Lyon Open after he suffered a 6-4 6-4 loss to Alex Molcan.
Eighth seed Pedro Martinez was knocked out by Yosuke Watanuki in the first round, but Karen Khachanov beat Gilles Simon 6-1 6-4 and Lucas Pouille was also beaten in his homeland, falling to Oscar Otte.