The Japanese qualifier posed little threat to the world number nine, who dropped just 11 points on serve as he cruised into the last eight.
The Serb is making his debut in Bangkok and is seeking his second title of the year as he aims to break into the world's top eight and qualify for the ATP Finals.
"I expected a tough battle," Tipsarevic said. "I saw him play in the US Open from the qualifying round.
"He also beat Robin Haase in the first round here, so I knew there would be no walk in the park. I should have won easily as I had break points in both sets. But I'm happy to win in straight sets."
Number seven seed Jarkko Nieminen also went through to the last eight, beating Germany's Philipp Petzschner 7-6(1) 6-2.
Frenchman Gael Monfils continued his comeback from injury with a first-round victory over Kevin Anderson, 6-4 2-6 7-5.
The world number 45 reached the semi-final in Metz last week after almost four months out with a knee problem and survived a scare to see off the South African qualifier.
Veteran Ivo Karlovic was also victorious in the first round in Thailand, defeating Marinko Matosevic 6-3 6-4 to set up a meeting against Milos Raonic of Canada.
Go Soeda of Japan defeated Danai Udomchoke 6-4 7-5 and will play Gilles Simon in the second round.