Tottenham can mathematically confirm finishing above Arsenal for the first time since 1995 with a win.
Mauricio Pochettino's side four points behind Chelsea, who face Everton at Goodison Park.
The final north-London derby at White Hart Lane, and Arsene Wenger's 50th as Arsenal manager.
Arsenal team and subs
Tottenham team and subs
Subs: Vorm, Walker, Wimmer, Dembele, Sissoko, Nkoudou, Janssen. #COYS
— Tottenham Hotspur (@SpursOfficial) 30 April 2017
What is it?
It's the north London derby at White Hart Lane. That's Tottenham versus Arsenal.
When is it?
Sunday 30 April.
What time is kick-off?
What TV channel is it on?
This is the final match in an absolutely huge Sunday of football. This game will be on Sky Sports 1.
Alternatively, you can follow the match with us on this page. We'll have build up and team news from about 3pm.
What is the team news?
Danny Rose is back in training but this match is likely to come too soon, while Mousa Dembele will have his ankle assessed before the game.
There are unlikely to be any surprises in Mauricio Pochettino's team.
Arsenal rate Laurent Koscielny as having a "60:40" chance of playing due to a knee problem.
Alex Oxlade-Chamberlain is fit and should play at right wing-back with Arsene Wenger expected to continue in the 3-4-2-1 formation that mirrors that of Tottenham and has brought three wins from three so far.
What are they saying?
Pochettino: "My feeling is now, when you are so close - only four points the gap - I will be very disappointed if we don't win the title.
"My challenge or my aim is not to be above Arsenal. My aim is to be above 19 teams and to be first, to be on the top.
"You cannot ignore Chelsea's game before us, but we played the day after they lost to Crystal Palace and it didn't affect our preparation."
Wenger: "This is one of the only times where Spurs look in people's minds as the favourites.
"I expect an open, committed match with high pace and there could be goals as both teams play positive football.
"I don't think that the top three is decided. We have an opportunity to be in there only if we win our games, we don't have to speculate at all.
"There is a lot that can happen until the end of the season."
What are the odds?
Tottenham win - 4/5 Draw - 3/1 Arsenal win - 3/1
What's our prediction?
It would be all too predictable for Spurs to mess this up, their greatest chance in years to assert their supremacy over Arsenal with a win at the home they will leave at the end of the season.
But they are a different team now, and should be able to get the victory they need. The atmosphere at White Hart Lane will be electric, and the players will be up for the challenge. We're going for:
Tottenham 2-1 Arsenal