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Officials: Referee: Andre Marriner, Assistants: S Beck, A Garratt, Fourth official: K Friend
Tottenham XI: Lloris, Dier, Alderweireld, Vertonghen, Walker, Wanyama, Dembele, Davies, Eriksen, Alli, Son.
Substitutes: Janssen, Vorm, Trippier, Sissoko, Onomah, Wimmer, Winks.
Southampton XI: Forster, Cedric, Stephens, Romeu, Yoshida, Davis, Bertrand, Ward-Prowse, Tadic, Redmond, Gabbiadini.
Substitutes: Long, Rodriguez, Caceres, Boufal, Hojbjerg, McQueen, Hassen.
Speaking to Standard Sport ahead of the match, Southampton legend Matt Le Tissier said his old side had 'nothing to fear' with Spurs' star man Kane sidelined.
"Their home form is absolutely outstanding so it's going to be a tough game," Le Tissier told Standard Sport.
"But - now Harry Kane is out it's a big blow. He's such a dominant force for them in terms of their goalscoring, as a leader and as a talisman.
"When such an important player in a team is missing it has an effect on the other players. They can look to him to get them out of trouble at times.
"If they do happen to go a goal down you look round the team and say 'right - where are we getting back into this?'"