Harry Kane is facing a spell on the sidelines with an ankle ligament problem and Mauricio Pochettino has put his faith in the South Korean to lead the north Londoners' front line against Claude Puel's side.
Danny Rose and Erik Lamela are still sidelined but Victor Wanyama and Kyle Walker have both overcome knocks to start.
Spurs appear to have stuck to a three-man defence and will need to keep in-form striker Manolo Gabbiadini quiet in order to maintain their stellar home record.
Spurs will tighten their grip on second place with victory this afternoon while the visitors are all-but assured of safety and will be aiming to solidify their place in the top 10.
Tottenham XI: Lloris (c), Walker, Dier, Alderweireld, Vertonghen, Davies, Wanyama, Dembele, Dele, Eriksen, Son.
Tottenham subs: Vorm, Trippier, Wimmer, Onomah, Sissoko, Winks, Janssen.
Southampton XI: Forster, Cédric, Stephens, Yoshida, Bertrand, Romeu, Davis (c), Ward-Prowse, Tadić, Redmond, Gabbiadini.
Southampton subs: Hassen, McQueen, Caceres, Hojbjerg, Long, Boufal, Rodriguez.
What they're saying
Mauricio Pochettino: "He [Vincent Janssen] needed a wake-up [call] to be reminded that the possibility of playing could arrive.
"He is very young. He came from Holland. I'm happy with him and all the players, but I understand they are not happy with some situations."
Claude Puel: “[Harry] Kane is an important player for them but they have other solutions with [Heung-min] Son, [Dele] Alli, Vincent Janssen and Christian Eriksen.
“They have many offensive players of quality so they can do without him."