Tottenham have just one forward, in Harry Kane, fit to start against Liverpool, though Dejan Kulusevski has returned to the bench.
It has been a difficult week on the injury front for the Spurs boss, with Heung-min Son needing surgery after suffering a facial fracture in the Champions League win over Marseille.
It is not yet clear whether Son will be fit in time for the World Cup, while Cristian Romero is set to miss Spurs’ final three games before the tournament because of muscle fatigue.
Rodrigo Bentancur was also struggling towards the end of the midweek fixture in France but has been passed fit, along with Lucas Moura but fellow Brazilian Richarlison remains out.
Tottenham: Lloris, Dier, Lenglet, Davies, Emerson, Bentancur, Bissouma, Hojbjerg, Sessegnon, Perisic, Kane
Subs: Doherty, Skipp, Sanchez, Gil, Forster, Kulusevski, Tanganga, Lucas Moura, Sarr
Liverpool: Alisson, Alexander-Arnold, Konate, Van Dijk, Robertson, Fabinho, Elliott, Thiago, Firmino, Salah, Nunez
Subs: Gomez, Henderson, Oxlade-Chamberlain, Jones, Tsimikas, Ramsay, Carvalho, Bajcetic, Kelleher