The Brazilian, who made a cameo in the north London derby defeat by Arsenal last weekend, was in contention to start ahead of the out-of-form Heung-min Son but the latter is usually effective against City, with manager Antonio Conte already predicting his side will enjoy no more than "20 or 25 per cent possession".
As a result Son keeps his place alongside Harry Kane and Dejan Kulusevski.
Rodrigo Bentancur returns to the midfield for the first time since before the World Cup after recovering from an adductor strain, with 20-year-old Pape Matar Sarr making way after a surprise full League debut against Arsenal on Sunday
Ivan Perisic comes in at at left wing-back after Conte's surprise decision to start Ryan Sessegnon at the weekend.
Emerson Royal gets the nod on the right over Matt Doherty, while it’s Ben Davies on the left of the back three.
Tottenham XI (3-4-3): Lloris; Romero, Dier, Davies; Royal, Bentancur, Hojbjerg, Perisic; Kulusevski, Kane, Son.
Subs: Forster, Tanganga, Doherty, Sanchez, Lenglet, Sessegnon, Bissouma, Sarr, Richarlison