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Chris Froome was forced to abandon the Tour de France on Thursday as the four-time champion tested positive for COVID-19.
The British rider sat 26th overall after Wednesday's stage 17, having spent over 69 hours on the road for the Israel Premier-Tech team.
The 37-year-old achieved his best Tour stage result since 2018 when he finished third on stage 12 up the Alpe d'Huez.
After a huge crash at the 2019 Criterium du Dauphine, Froome was left in intensive care with multiple serious injuries. He looked nailed on for his best general classification result in a Grand Tour since then as the riders edged closer to the finish in Paris this Sunday.
However, in a video message posted on his Twitter page, Froome said he had received "pretty disappointing news".
"A test has revealed that I've contracted COVID, so I'm not going to be taking the start today," he said.
"I'm really disappointed not to be able to roll into Paris and finish off this Tour de France. It's been an extremely special race for us as a team and me personally as well. I've been finding my legs again.
"I'm going to head home now, switch off for a few days, and refocus on being ready for the Vuelta a Espana later this season."
The Vuelta begins in the Netherlands on August 19, with a time-trial opener in Utrecht, before taking place in Spain from stage four onwards.