Brunson (20-7) enters on the back of two consecutive wins – over Ian Heinisch and Elias Theodorou – while fellow American Shahbazyan is undefeated at 11-0.
Eighth-ranked Brunson and ninth-ranked Shahbazyan are both competing for the first time this year as they look to close the gap to champion Israel Adesanya, who defeated Brunson in 2018.
In the co-main event, Scotland’s Joanne Calderwood takes on Jennifer Maia in a women’s flyweight bout. Elsewhere on the main card, Vincente Luque clashes with Randy Brown in a welterweight contest.
Here’s all you need to know about this evening’s Fight Night from Las Vegas:
What time does the event start in the UK?
The main card starts at 2am BST on Sunday. The preliminary card begins at 12am BST.
Brunson and Shahbazyan will likely make their ring walks for the main event at around 4am BST on Sunday.
How can I watch it?
The main card and prelims will air on BT Sport 1 in the UK. Both of these parts of the show can also be streamed on the BT Sport website and app.
Viewers in the US can watch the event on ESPN+.
What’s the full card?
Derek Brunson vs Edmen Shahbazyan (middleweight)
Joanne Calderwood vs Jennifer Maia (women’s flyweight)
Vincente Luque vs Randy Brown (welterweight)
Lando Vannata vs Bobby Green (lightweight)
Ed Herman vs Gerald Meerschaert (light heavyweight)
Kevin Holland vs Trevin Giles (middleweight)
Frankie Saenz vs Jonathan Martinez (bantamweight)
Johnny Munoz vs Nate Maness (bantamweight)
Jamall Emmers vs Vince Cachero (featherweight)
Chris Gutierrez vs Cody Durden (bantamweight)