Against their fellow Euroleague newcomers, Unics started slowly and trailed for almost 38 minutes at the Abdi Ipekci Sports Hall before waking up in the final quarter to edge the contest.
Back-to-back three-pointers from Mike Wilkinson and Terrell Lyday put the visitors ahead for the first time with just over two minutes to play.
It was a lead the Russian side were not to relinquish as they held out to record their debut victory in the competition and take their record in Group D to one and one.
Far less straightforward was
Led by Nicolas Batum, who ended with 26 points, Nancy scored 15 unanswered points in the final three minutes to pull away and claim their first victory in Group A.