On what is expected to be her final tournament appearance, Williams ensured she got more than one match in New York at least as she defeated Danka Kovinic 6-3 6-3, setting up a clash with the second seed Anett Kontaveit.
Murray, meanwhile, claimed his first straight sets win in a grand slam since 2017 as he swept past Francisco Cerundolo. Murray now faces the American Emilio Nava as the former US Open champion looks to reach the third round of a grand slam for only the second time since 2018.
Elsewhere, Britain’s Jack Draper takes on the sixth seed Felix Auger-Aliassime, Kyrgios is back in action against Benjamin Bonzi, and Harriet Dart plays Dalma Galfi after her excellent opening win over Daria Kasatkina.
Here’s everything you need to know ahead of the second round of the US Open.
What TV channel is it on in the UK?
The US Open will be shown live on Amazon Prime in the UK, with all matches from the tournament available to stream on Prime Video which is available on Smart TVs and the Prime Video app as well as online. If you’re not an Amazon Prime Video subscriber start a free 30-day trial here.
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What is the order of play?
(All times local, -5 hours from BST)
Arthur Ashe Stadium
12:00: Andy Murray (Gbr) v Eduardo Nava (USA), Elena Gabriela Ruse (Rom) v (12) Cori Gauff (USA), Serena Williams (USA) v (2) Anett Kontaveit (Est), (1) Daniil Medvedev (Rus) v Arthur Rinderknech (Fra)
Louis Armstrong Stadium
11:00: Xiyu Wang (Chn) v (3) Maria Sakkari (Gre), (20) Madison Keys (USA) v Camila Giorgi (Ita), (23) Nick Kyrgios (Aus) v Benjamin Bonzi (Fra), Jack Draper (Gbr) v (6) Felix Auger-Aliassime (Can), (15) Beatriz Haddad Maia (Bra) v Bianca Vanessa Andreescu (Can)
11:00: (5) Ons Jabeur (Tun) v Elizabeth Mandlik (USA), Hugo Grenier (Fra) v (13) Matteo Berrettini (Ita), (29) Tommy Paul (USA) v Sebastian Korda (USA), (14) Leylah Annie Fernandez (Can) v Ludmilla Samsonova (Rus)
11:00: Christian Garin (Chi) v (18) Alex De Minaur (Aus), Anna Karolina Schmiedlova (Svk) v Shuai Zhang (Chn), Alejandro Tabilo (Chi) v Jeffrey John Wolf (USA), Anna Kalinskaya (Rus) v (17) Caroline Garcia (Fra)
11:00: Peyton Stearns (USA) v (28) Ekaterina Alexandrova (Rus)
11:00: (12) Pablo Carreno-Busta (Spa) v Alexander Bublik (Kaz), Daria Snigur (Ukr) v Rebecca Marino (Can), Daniel Elahi Galan (Col) v Jordan Thompson (Aus), Aleksandra Krunic (Ser) v (23) Barbora Krejcikova (Cze)
11:00: Brandon Holt (USA) v Pedro Cachin (Arg), Dalma Galfi (Hun) v Harriet Dart (Gbr), Alejandro Davidovich Fokina (Spa) v Marton Fucsovics (Hun), Evgeniya Rodina (Rus) v Ajla Tomljanovic (Aus)
11:00: Corentin Moutet (Fra) v (21) Botic Van de Zandschulp (Ned), (18) Veronika Kudermetova (Rus) v Maryna Zanevska (Bel), Nuno Borges (Por) v Yibing Wu (Chn)
11:00: Jaume Munar (Spa) v Roberto Carballes Baena (Spa)
11:00: Jason Kubler (Aus) v Mikael Ymer (Swe)
11:00: Viktoria Kuzmova (Svk) v (31) Shelby Rogers (USA), (29) Alison Riske-Amritraj (USA) v Maria Camila Osorio Serrano (Col), Tim Van Rijthoven (Ned) v (5) Casper Ruud (Nor), (27) Karen Khachanov (Rus) v Thiago Moura Monteiro (Bra)