The fiery Australian will hope to cause an upset as he pursues a first grand slam following a final appearance at Wimbledon this summer.
While Coco Gauff returns as the new darling of American tennis, with fans likely to turn attention to her after Serena Williams’ exit at the hands of Ajla TomljanoviÄ.
Look out for another contender in the women’s singles, as Ons Jabeur faces Veronika Kudermetova on Arthur Ashe.
Here is all you need to know about Sunday’s schedule.
What is the order of play?
All times local
ARTHUR ASHE STADIUM
Corentin Moutet (France) v 5-Casper Ruud (Norway)
Zhang Shuai (China) v 12-Coco Gauff (United States)
1-Daniil Medvedev v 23-Nick Kyrgios (Australia)
3-Ons Jabeur (Tunisia) v 18-Veronika Kudermetova
LOUIS ARMSTRONG STADIUM
Alejandro Davidovich Fokina (Spain) v 13-Matteo Berrettini (Italy)
17-Caroline Garcia (France) v 29-Alison Riske-Amritraj (United States)
12-Pablo Carreno Busta (Spain) v 27-Karen Khachanov
Liudmila Samsonova v Ajla Tomljanovic (Australia)
What TV channel is it on in the UK?
The US Open will be shown live on Amazon Prime in the UK, with all matches from the tournament available to stream on Prime Video which is available on Smart TVs and the Prime Video app as well as online. If you’re not an Amazon Prime Video subscriber start a free 30-day trial here.
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