The sixth seed raced through the first set and needed just one hour, 38 minutes to take his place in the last eight at Flushing Meadows for only the second time in his career.
"I'm very happy with today's win," Berdych said. "I'd like to point out one thing which was the key, when I was 0-40 down in the first game on serve, and I saved it.
"That was a nice boost in the beginning and from then on I played well. Everything worked today, job done, that's good."
In the quarter-finals, Berdych will play Croatia's Marin Cilic, who earlier edged out Gilles Simon of France in five sets.
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