Al Rayyan Stadium hosts two teams determined to get off to a good start in Group B, having already witnessed England thrash Iran earlier in the day.
Tonight’s clash pits a Welsh team that last made the World Cup in 1958 against a United States outfit back after surprisingly missing out four years ago in Russia.
Christian Pulisic and Gio Reyna are the US’s leading lights while Gareth Bale is expected to once again be the Dragons’ talisman.
Here are all the details for tuning in...
Where to watch USA vs Wales
TV channel: In the UK, the match will be televised free-to-air and live on ITV1, with coverage beginning at 6pm before a 7pm GMT kick-off. S4C will be showing Welsh language coverage of every Wales match during the tournament.
Live stream: The ITV Hub will show the match live online.
Live blog: You can follow all the action via Standard Sport’s live blog.