Mercedes reserve driver Nyck de Vries is set to make his Formula One debut in Monza, filling in for Williams' Alex Albon after he was ruled out of contention.

Albon travelled to a local hospital for treatment for appendicitis on Saturday and it was announced he would not race in the Italian Grand Prix.

Instead, De Vries will drive for Williams in his place in an opportunity for him to impress ahead of a potential spot on the grid in 2023.

"Williams Racing can confirm that, after feeling unwell this morning and seeking medical advice from the FIA and local hospital, Alex Albon is now undergoing treatment for appendicitis," the team's statement said.

"Following on from this, we can confirm that the team's reserve driver Nyck de Vries will drive in place of Alex for the remainder of the Italian Grand Prix weekend.

"Alex is in good spirits and the team wishes him a speedy recovery."

De Vries had already been involved in the week's events at Monza, driving for Aston Martin in the first free practice session, and has said he feels he deserves an opportunity to drive next season.

"Obviously, it's a dream and I think I would deserve a chance, but ultimately it's not up to me to decide a driver line-up," he told reporters.

Mercedes team principal Toto Wolff has also previously backed De Vries for a seat in 2023, though conceded he is unable to help and the team may have to let him go with George Russell and Lewis Hamilton on their books.

"If we are not able to provide him [De Vries] with an interesting Formula One project, in a way we need to let him go," he told Sky Sports during the French Grand Prix weekend.

"He's looking at various options - sportscars and maybe Formula E, but you must never give up on the opportunity that one day a Formula One door can open. He has been very good and I can't really help him."

Alpine, Williams, Haas, Alfa Romeo and AlphaTauri are all yet to confirm their full driver line-up for 2023, leaving five spots on the grid.