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Wales wing Alex Cuthbert has been ruled out of this weekend's series decider against South Africa with a shoulder injury.
The 32-year-old was forced off the field 17 minutes into the visitors' 13-12 victory in Bloemfontein on Saturday, which levelled the three-match series at 1-1.
Wales confirmed on Monday that Cuthbert will play no part in the third and final Test, with no replacement being called up.
Josh Adams, who replaced Cuthbert and scored Wales' late try, is now expected to start the crunch clash in Cape Town.
Captain Dan Biggar and prop Dillon Lewis suffered shoulder and arm injuries respectively in the second Test, but they have not yet been ruled out.
South Africa confirmed earlier on Monday that centre Andre Esterhuizen, who started for the much-changed hosts last time out, will play no part after breaking his hand.