The PPV showdown has the young Brit, in his first-ever world title fight, facing off with the Ukrainian fighter in what is expected to be a cauldron of noise in Wroclaw, Poland.
Even the undercard is stacked with Ukraine’s best boxing talent for what should be a memorable night of boxing.
In the main event, Usyk is expected to dominate Dubois and continue on the pathway to a mouthwatering unification clash with Tyson Fury. Dubois has won four fights in a row and a victory later today would be one of the shocks of this heavyweight generation.
How to watch Usyk vs Dubois
TV channel: In the UK, the fight will be shown on TNT Sports Box Office for a pay-per-view price of £19.95. Coverage begins at 6pm BST.
Live stream: PPV subscribers can watch online via the TNT Sports Box Office app and website, as well as via Sky, Virgin or BT TV. You do not need to be a regular TNT Sports subscriber to access the PPV service.
Live blog: Fight fans can also follow the entire card round-by-round via Standard Sport’s fight night blog!