Packers head coach Matt LeFleur opted to do the bulk of their preparation in Green Bay before flying to London on Thursday evening, with a Friday morning local time arrival.
LaFleur said the game "feels like a Thursday night game" for the coaches in terms of preparation turnaround, but Rodgers laughed that off from a player's perspective.
"Listen, coaches are creatures of habit, even more than players," Rodgers told reporters on Wednesday.
"Anytime there's a minute adjustment to the schedule, it throws them all out of whack, so I wouldn't read too much into that.
"Obviously the time we're leaving might put a little stress on the schedule, but that's way down at the bottom of the concerns… We'll be ready to go."
Rodgers had no complaints about the decision to travel late in the week, although he admitted he would have liked to take in London for a cultural experience.
"We're all excited," he said. "I think the reason I said I wanted to go over early was just to experience a little bit of that culture, to be able to get out and see some sights and interact with fans, go to a pub and have a Guinness or whatever the local brew is.
"That's what we all want to do, those of us that want to go over early."
The four-time NFL MVP said he had his own techniques to deal with jetlag, preferring to keep them secret for a "competitive advantage", but offered some insight into the coming days.
"You knock yourself out," he laughed. "You've got to stay up as late as you can Friday and then it starts to fall into place. But there's no excuses, we'll be trying to sleep on the way out.
"We'll go through the process on Friday, trying to sleep Friday night, hoping for a bit more rest Saturday, have a normal day, get some sleep but both teams are dealing with the same issues."
The Packers have won three straight games to hold a 3-1 record and sit second in the NFC North, while the Giants are also 3-1.
Rodgers has made 89 of 129 attempts with a completion rate of 69 per cent for six touchdowns with three interceptions across four games this season.
This will be the first of the 32 NFL games held in London to feature both teams with winning records.