The third-round clash pits one of the Premier League’s more underperforming teams against a Rovers side pushing for promotion out of the Championship.
This competition has never been won by two-time finalists West Ham, although they have reached the quarter-finals in three of the past six seasons.
Jon Dahl Tomasson has vowed to rotate his side for the trip, which comes ahead of a huge local derby with promotion rivals Burnley this weekend.
Here are all the details...
Date, kick-off time and venue
West Ham vs Blackburn is scheduled for a 7.45pm GMT kick-off tonight, Wednesday November 9, 2022.
London Stadium will host the match.
Where to watch West Ham vs Blackburn
TV channel and live stream: The match will not be broadcast live on TV in the UK.
West Ham vs Blackburn team news
West Ham XI: Areola, Johnson, Aguerd, Ogbonna, Coufal, Coventry, Lanzini, Emerson Palmieri, Downes, Antonio, Fornals
Subs: Cresswell, Zouma, Scamacca, Dawson, Bowen, Benrahma, Soucek, Randolph, Hegyi
Blackburn XI: Pears, Rankin-Costello, Carter, Mola, Edun, Buckley, Adam Wharton, Markanday, Dack, Dolan, Vale
Subs: Kaminski, Hyam, Morton, Szmodics, Hirst, Brereton, Garrett, Phillips, Batty
West Ham vs Blackburn prediction
Both teams are well-versed in the midweek grind of fixtures but the Hammers should have the quality in this one.
A 1-0 West Ham win.
Head to head (h2h) history and results
Rovers have only beaten their opponents on Wednesday night once in over 20 years.
West Ham wins: 43
Blackburn wins: 45
West Ham vs Blackburn match odds
West Ham: 1/3
Odds via Betfair (subject to change).