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Pep Guardiola’s side have been the dominant outfit in the competition of late thanks to their tremendous squad depth and desire to lift silverware.
But the Hammers have been excellent this term and already dispatched Manchester United in the last round, so they’ll have every reason to be optimistic of causing another upset here.
City saw off Wycombe in the third round, but this will be a much greater challenge against the side currently fourth in the Premier League.
Here’s everything you need to know ahead of the match.
When is the match?
The game kicks off at 7:45 pm on Wednesday, 27 October at the London Stadium.
Where can I watch it?
This fixture is not scheduled for live broadcast on UK TV.
WHU - Areola, Johnson, Dawson, Diop, Cresswell, Masuaku, Soucek, Noble, Lanzini, Vlasic, Yarmolenko
MNC - Steffen, Walker, Stones, Ake, Zinchenko, Fernandinho, Gundogan, De Bruyne, Mahrez, Sterling, Palmer
West Ham 33/5
Man City 1/2
If the Hammers go with a strong line-up and City rotate, they could be the ones to finally end City’s dominance of this competition - but that’s a big ask considering their European exploits too. Big changes to the team could make it one-way traffic. West Ham 1-3 Man City.