West Ham's 3-0 win over Sheffield United kept them firmly in the race for the Premier League's top four, and now a more testing run of games will decide whether or not they stay there.
Moyes reverted to the back-three system which saw them through this difficult run so well earlier in the season against the Blades, and will be minded to stick with it against Jose Mourinho's side.
With Angelo Ogbonna out for some time with an ankle injury, the shift to a three, which becomes a five off the ball, brings a touch more solidity and comfort at the back.
Aaron Cresswell has excelled on the left of a back three and still manages to contribute going forward, while Ben Johnson impressed at left wing-back on Monday night.
In Antonio's absence, Jarrod Bowen was played through the middle against Sheffield United, and while Moyes can be flexible going forward, his talisman will return if his training continues uninterrupted over the weekend.
“Michail has a good chance of being available for Sunday because he’s had three days training,” Moyes said on Friday.
“We’ve always been careful with Mich in trying to get him right, but he was close for the last game. We didn’t quite think it was worth the risk.
“He’s not been training with the group every day, but he’s been doing some individual work and hopefully we’ll know a bit more tomorrow.”
Manuel Lanzini linked up well with Jesse Lingard and Bowen on Monday night, but Pablo Fornals - who has had to be patient for chances in recent weeks - offers more off the ball against bigger sides and could be set to return against Spurs.
West Ham: Fabianski, Coufal, Diop, Dawson, Cresswell, Soucek, Rice, Bowen, Lingard, Fornals, Antonio
Subs:Balbuena, Benrahma, Lanzini, Alves, Noble, Martin, Johnson, Randolph, Odubeko
Tottenham:Lloris, Tanganga, Sanchez, Dier, Reguilon, Hojbjerg, Ndombele, Lucas Moura, Lamela, Son, Kane
Subs: Doherty, Alderweireld, Winks, Bale, Hart, Sissoko, Alli, Davies, Vinicius
Sunday 12pm, Sky Sports
Venue: London Stadium
Referee: Craig Pawson
West Ham squad from: Fabianski, Martin, Randolph, Diop, Dawson, Alves, Fredericks, Coufal, Johnson, Cresswell, Noble, Rice, Soucek, Fornals, Lanzini, Lingard, Benrahma, Bowen, Odubeko, Antonio
Unavailable: Masuaku (knee), Ogbonna (ankle), Yarmolenko (knee)
Doubt: Balbuena (calf)