The German was expected to lead the Reds as usual as they look to sign off for the World Cup with a victory at Anfield over a Saints side hoping for a new manager bounce under Ralph Hasenhuttl’s successor, Nathan Jones.
However, Klopp will not be on the touchline after all as he serves a one-match ban following key developments on Friday.
The issue stems back to Liverpool’s pulsating 1-0 top-flight win over Manchester City on October 16, when he was sent off by referee Anthony Taylor for screaming in the face of the assistant referee after a free-kick was not awarded for an apparent foul by Bernardo Silva on match-winner Mo Salah.
Klopp initially escaped a touchline ban for those antics after being hit with and accepting a Football Association (FA) charge of misconduct, but was fined £30,000 for breaching FA Rule E3.
However, that decision was subject to appeal by the FA or Klopp after receiving the written reasons from the independent regulatory commission.
The FA did indeed decide to appeal after feeling that ruling was too lenient, with such a challenge upheld on Friday as Klopp now serves an immediate one-match suspension.
“An independent Appeal Board has allowed the FA’s appeal against an Independent Regulatory Commission’s sanction in relation to the recent case involving Jurgen Klopp,” an FA statement read.
“As a result, the Liverpool FC manager has been suspended from the touchline for one match with immediate effect, fined £30,000 and warned as to his future conduct.
“Jurgen Klopp has previously admitted that he breached FA Rule E3 during their Premier League match against Manchester City FC on Sunday, October 16 and received a sanction £30,000.”
With Klopp absent, Pep Lijnders will be the prominent figure on the Liverpool touchline at Anfield this afternoon, along with fellow assistant Peter Krawietz.