Wiggins scored a season-high 36 points on 14-of-19 field shooting with a joint career-high eight three-pointers, including three in a row in the third quarter at the Chase Center.
Curry added 30 points, including eight triples, as well as providing 10 assists for Golden State, who have won five of their past six games.
The Warriors shot 25-of-52 from three-point range as a team, compared to the Rockets who went at 10.7 per cent from beyond the arc, making three-of-28 attempts.
Golden State became the second team in NBA history to make 20 three-pointers in four of five games.
Gobert ejected in Timberwolves defeat
The French center was given a flagrant 2 foul and ejected in the second quarter when he tangled with Williams, appearing to sweep a leg out while on the ground, seeing his unbalanced opponent tumble.
Shai Gilgeous-Alexander top scored for OKC with 33 points and six assists, while for the Timberwolves, who were already without Karl-Anthony Towns (calf), D'Angelo Russell and Anthony Edwards scored 27 and 26 points respectively.
Short-handed Bucks down Hornets