Coach Tony Smith chose to rest seasoned campaigners Adrian Morley, Trent Waterhouse, Simon Grix, Michael Monaghan and Lee Briers with Monday's trip to Catalan Dragons in mind and the gamble looked to have backfired when his side trailed 12-0.
But the Wolves roared back with 46 unanswered points to take the spoils from the first Super League derby with Widnes since 2005.
Hooker Scott Moore and scrum-half Rhys Hanbury worked the ball out to the right, where centre Chris Dean touched down, and second rower David Allen then took Hanbury's short pass to crash over on the burst.
Patrick Ah Van added both goals and the Vikings were good value for their lead but Warrington gradually settled into the game once they stopped conceding needless penalties.
England centre Chris Bridge, switched to the pack in the absence of four forwards, started the fightback with two tries in three minutes, finishing off a break by the lively Gareth O'Brien and then dummying his way over for a solo score.
Acting captain Brett Hodgson added both conversions to tie the scores and, after Joel Monaghan was denied a try for a forward pass, the Wolves went in front on 28 minutes when centre Ryan Atkins worked his winger Chris Riley over at the corner.
Warrington missed another glorious chance when Richie Myler failed to find unmarked winger Rhys Williams and the Wolves had a let-off early in the second half when Hanbury did wonderfully well to reach the line but lost control of the ball.
Bridge hobbled off, shortly after being held up over the line as he attempted to complete his hat-trick, but there was no way back for Widnes when Hodgson took Myler's pass to dummy his way over on 51 minutes and Atkins tip-toed down the wing for the home side's fifth try five minutes later.
As the visitors tired under incessant pressure on their own line, Brad Dwyer nipped over from close range for his first try for the club and Riley squeezed over twice in the last four minutes to complete his hat-trick.
Elsewhere, Vincent Duport and Louis Anderson both crossed for two tries as the
Duport and Anderson struck once either side of the interval as the visitors claimed a deserved triumph.
Shane Rodney, Luke Dorn and Michael Robertson all crossed for Broncos.
The first score was not long in coming as the Catalans romped home when Leon Pryce started a stunning move that saw Anderson surge over and it was the visitors who bossed the opening 15 minutes, claiming their second score when Duport profited after Pryce's kick unsettled the London defence.
Minutes before half-time the home side were given a lifeline when Damien Blanch knocked on near his own line, Rodney powering over to reduce the deficit from the resulting scrum.
It was the Dragons who seized the initiative five minutes into the second half, Duport claiming his second score after the Broncos were penalised close to their own posts.
Just as in the first half the away side really had their tails up, and Anderson helped himself to his second try of the game moments later, finishing off Scott Dureau's kick.
London's defence was non-existent, and the French side were close to securing the points when they grabbed their third try in the space of five minutes, Steve Menzies romping over from close range and Dureau then burst over himself as the Dragons once again cut the men from the capital to ribbons.
To their credit the hosts did splutter back into life again after 63 minutes, Dorn speeding through after Antonio Kaufusi was held just short. And there was more cheer for the Londoners five minutes later, Michael Robertson barging through a handful of tackles to score.
Ian Henderson was then sin-binned after a late hit, but it was Pryce who was to have the final say, bursting over for a late try of his own.