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Netherlands star Vivianne Miedema has tested positive for COVID-19, ruling her out of the Oranje's Group C fixture with Portugal on Wednesday.
Miedema scored 14 goals in 22 Women's Super League appearances for runners-up Arsenal last season, a tally only bettered by Chelsea's Sam Kerr (20).
The 25-year-old, widely regarded as one of the best players in the women's game, has also netted an incredible 94 goals in 112 international appearances, making her the Netherlands' all-time leading scorer.
Miedema started her country's Euro 2022 opener on Saturday, a 1-1 draw with Sweden, but coronavirus will prevent her facing Portugal.
An update from the Oranje's Twitter account read: "Vivianne Miedema has unfortunately tested positive for COVID-19 and will therefore be in isolation for the next few days.
"When she no longer has any symptoms and tests negative, she can re-join the selection."
Miedema has scored 11 goals for the Netherlands since head coach Mark Parsons took charge last year – no Dutch player has more – and netted four times as the side won the last edition of the Women's Euros in 2017, including a brace in a 4-2 final win over Denmark.
It remains unclear whether the Arsenal forward will be back in action by the time the Netherlands finish their Group C campaign against Switzerland at Bramall Lane on Sunday.