Wests Tigers have withdrawn contract offers for captain Aaron Woods and star full-back James Tedesco, the club announced on Friday.
Woods and Tedesco are in the final season of their respective deals with the Tigers, who had hoped to secure their long-term futures after Mitchell Moses agreed to join Parramatta Eels from 2018.
However, the 2005 NRL champions risk losing the influential pair after failing to reach an agreement by a deadline they set for Friday.
An official club statement read: "When Wests Tigers met with Aaron Woods and James Tedesco's manager on Tuesday a deadline of 5pm Friday was set to secure certainty for the club.
"That deadline has now passed and Wests Tigers is yet to receive any official confirmation from the pair's manager.
"As a result Wests Tigers has removed the current long-term contract offers that were with their management.
"Wests Tigers are proud of everything Aaron and James have achieved and will continue to achieve throughout the season at this club."
Tedesco has been linked with a switch to Sydney Roosters, while Woods is said to be approaching a switch to the Bulldogs.