In an outspoken video, the Royal criticised what he called “political failure” to tackle both HIV and Covid - saying monopolies on vaccine production must be ended.
He said: “There are striking parallels between Covid-19 and another deadly pandemic - one that emerged 40 years ago - HIV.
“This is a story about how corporate greed and political failure have prolonged both pandemics, and what we can do to stop it.”
Princess Diana, who was known for raising awareness around HIV/Aids, featured in footage for the clip.
Drawing on the history of the HIV pandemic, the prince said: “In the early 2000s a wave of activism helped break drug company monopolies, helping give millions of people access to generic medicines at a fraction of the price.”
During the #AIDS crisis, pharmaceutical companies have made vast profits, while millions have been left behind.
History is repeating itself.
This #WorldAidsDay, I join Prince Harry, The Duke of Sussex & millions of others, again fighting for change. pic.twitter.com/x6FWVWcjq8
— Winnie Byanyima (@Winnie_Byanyima) December 1, 2021
The video also shows Harry telling a cheering audience: “Many of these vaccines were publicly funded, they’re your vaccines - you paid for them.”
He goes on to add: “By ending vaccine monopolies and sharing technology, companies in the developing world can start producing Covid vaccines too.”
The video, released by a coalition of 80+ organisations demanding Covid vaccines be freely available to everyone, also features the Executive Director of UNAIDS Winnie Byanyima.
Ms Byanyima said: “Both have caused millions of deaths and in both cases scientific breakthroughs have meant that for many life could begin again.”
She added: “Then it was access to the first antiretroviral drugs and now it’s Covid-19 vaccines, and once again pharmaceutical companies are making vast profits in the rich world off life-saving medical advances while the poor are being left behind.”
Warning of the dangers of not sharing life-saving vaccines, the video estimates around 12m people died in Africa alone of HIV before access to life-saving drugs became widespread.
The head of the World Health Organisation, Dr Tedros Adhanom Ghebreyesus, strongly criticised rich countries earlier this month for stockpiling vaccines while poorer countries went without.
“Every day, there are six times more boosters administered globally than primary doses in low-income countries,” he said. “This is a scandal that must stop now.”