New York Yankees pitcher Luis Severino is set to miss the start of the MLB season due to a low-grade right lat strain.

Yankees manager Aaron Boone on Saturday revealed Severino will not throw for at least five days.

The two-time All-Star was due to start Yankees' second game of the season against the San Francisco Giants next Saturday, but looks likely to instead be on the injured list.

Clarke Schmidt is expected to get a start in the absence of Severino, with Gerrit Cole the man to open up in the first game of the season versus the Giants on Thursday.

Severino missed over two months with the same injury last season.

The 29-year-old has an ERA of 9.00 this spring, having allowed 15 runs in as many innings.

The Yankees are also without Carlos Rodon (forearm strain) and Frankie Montas (shoulder surgery) heading into the new season.