Much of the focus at the All-Star Game will be on the headline event and the Slam Dunk Contest, but the Rising Stars Challenge also offers great intrigue.
Zion Williamson, Ja Morant, Luka Doncic and Trae Young will all be involved as Team USA take on Team World.
With the early success that quartet have enjoyed in their fledgling careers, the Rising Stars Challenge should serve as further compelling evidence the future of the NBA is in good hands.
Here we guide you through what to watch for when the league's brightest talents do battle.
ZION & JA TEAM UP
Williamson and Morant appear poised to contest a fascinating rivalry over the course of their careers, but on Friday they will be on the same side.
Number one overall pick Williamson, sidelined for much of the year with a knee injury, and Rookie of the Year favourite Morant went head-to-head two weeks ago and offered a glimpse into the future as Zion's New Orleans Pelicans beat the Memphis Grizzlies.
The Rising Stars Challenge will provide a window into how the pair's talents complement each other, which could potentially be crucial for future USA Olympic coaches.
With Morant set for a prestigious honour and Williamson having recorded two double-doubles in eight games, Team World will have a hard time slowing them down.
DONCIC DOUBLES UP
Likely to finish high in the MVP voting, Doncic will - along with Young - double up at All-Star weekend.
The Dallas Mavericks guard will contest the All-Star Game as well as the Rising Stars Challenge, having been picked as a starter for Team LeBron.
With the odds in favour of Team USA winning the Rising Stars Challenge, Doncic's best chance of success in Chicago should be in the headline event.
While Williamson, Morant and Doncic will claim most of the attention among the rising stars, there are several less heralded players with the chance to snatch some of the limelight.
Jaren Jackson Jr. and Canadian Brandon Clarke will face off having played an instrumental role in the Grizzlies' rise to playoff contention.
Shai Gilgeous-Alexander should be crucial to Team World's hopes, his development unhindered by a trade from the Los Angeles Clippers to the upstart Oklahoma City Thunder.
Eric Paschall's opportunities to shine on a national stage have been limited thanks to the demise of the Golden State Warriors this season, but the forward will have the chance to prove he is the Dubs' latest second-round gem.
YOUNG TRIBUTE TO KOBE
Proceedings at the United Center are set to be dominated by tributes to Kobe Bryant and his daughter Gianna, who were killed in a helicopter crash last month.
In the wake of their tragic passing, an emotional Young - having been mentored by Bryant - scored 45 points in the Atlanta Hawks' win over the Washington Wizards.
With two games on his agenda, Young will have ample opportunity to honour his idol by delivering on the court in his first appearance at the weekend as an All-Star.