Saints went top of the table for the first time in the Premier League era in November but their season is now unravelling at a rate of knots.
The Mali international went down after a robust challenge by Everton's Dominic Calvert-Lewin and although he has trained this week, Hasenhuettl is not taking any chances ahead of Saturday's match with Sheffield United. "We have to pay attention with him because he has a big injury history since he's here," Hasenhuettl told reporters, referring to Djenepo's thigh, calf and hamstring injuries.