Holders Manchester United welcome Ruud van Nistelrooy back to Old Trafford in the FA Cup fourth round for an intriguing tie against Leicester City.

Having seen off Arsenal in a dramatic penalty shootout on Sunday, United were immediately drawn against their former interim head coach now at Leicester.

The tie is among three all-Premier League fixtures, including Brighton & Hove Albion welcoming Chelsea, Aston Villa facing Tottenham Hotspur and Everton hosting Bournemouth.

Ruben Amorim, who had the option of retaining Van Nistelrooy on his staff, said he is looking forward to facing the Dutchman.

“I talked with him before I came,” Amorim said after victory at the Emirates. “I’m looking forward to speaking with him. He’s a class guy but we need to win. Maybe we’ll be divided because he loves this club but we need to win.”

Other standout ties include Plymouth Argyle being rewarded for their shock third round victory against Brentford with a mouth-watering fixture against Premier League leaders Liverpool.

The Devon club, resurgent since sacking Wayne Rooney but still in deep relegation trouble in the Championship, will be thrilled to be welcoming the likes of Mohamed Salah to Home Park. Manchester City, meanwhile, face a potential banana skin visit to Leyton Orient or Derby County.

FA Cup fourth-round draw in full

Manchester United vs Leicester City
Leeds United vs Millwall/Dagenham & Redbridge
Brighton vs Chelsea
Preston/Charlton vs Wycombe
Exeter vs Nottingham Forest
Coventry City vs Ipswich Town
Blackburn Rovers vs Wolves
Mansfield Town/Wigan vs Fulham
Birmingham vs Newcastle
Plymouth Argyle vs Liverpool
Everton vs Bournemouth
Aston Villa vs Tottenham
Southampton/Swansea vs Burnley
Leyton Orient/Derby County vs Manchester City
Doncaster Rovers vs Crystal Palace
Stoke vs Cardiff

Ties will be played between February 7 and 10.