The fixture that could end Arsenal's Premier League title dream and it's not North London Derby

Mikel Arteta shakes hands with Erik ten Hag ahead of Arsenal's clash with Manchester United

Arsenal opened up a four-point lead in the Premier League title race on Tuesday night with a 5-0 hammering of London rivals Chelsea. And with just four games to go they are in pole position to lift the crown for the first time in 20 years.

But, they have played a game more than Liveprool - who are three points behind - and two games more than Manchester City - who are four points behind. Crucially though, with that 5-0 win, they have opened up a 13-goal advantage over Liveprool in the goal difference column and a 12-goal advantage over City, which could be pivotal.

That would mean if City were to drop points and draw one game in the run-in and Arsenal win all of theirs, they would go on and win the title on goal difference - providing City do not make up those 12 goals in their two games in hand of course.

This weekend could be a pivotal one for Arsenal in the title race. That is because they face off against their arch-rivals Spurs at the Tottenham Hotspur Stadium. Tottenham will be doing everything they can, not just to stunt the Gunners' title ambitions, but also to help in their quest to finish fourth and qualify for next season's Champions League.

City also have to travel to N17, but that looks to be the toughest fixture in their run-in, with the rest of the matches, on paper at least, looking good for the reigning champions. However, there is one other for Arsenal that could prove problematic, and perhaps even more tricky than the North London Derby clash.

The penultimate weekend of the season could also be a pivotal one in determining in whose trophy cabinet the Premier League trophy sits come the end of the season.

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All three title contenders are away from home on that weekend. Arsenal face the daunting trip to Old Trafford to take on Manchester United, while Liverpool go to Aston Villa and Man City make the trip to Fulham.

None of those matches look particularly easy, with Villa gunning for a Champions League spot and Fulham enjoying a fine home record this season, having beaten both Arsenal and Tottenham at Craven Cottage this year.

However, Liverpool have beaten Villa eight times in the last ten seasons at Villa Park, while City have won seven of the last ten trips to Fulham in the Premier League, losing none of them.

Arsenal, meanwhile, have an unenviable record away at United. The Gunners have won just once at the home of the Red Devils in the last ten campaigns, drawing five times and losing on four occasions. As much as supporters may be fearing the Spurs match, it is the United one, given the other two teams' fixtures on that weekend, that could have the biggest fear factor.