Jose Antonio Reyes has died in a car crash, his former club Sevilla have confirmed.

The 21-cap former Spain international, who made 22 appearances for Arsenal’s unbeaten ‘Invincibles’, was in a crash while in Spain.

Sevilla wrote in a tweet: "We couldn't be confirming worse news. Beloved Sevilla star José Antonio Reyes has died in a traffic collision. Rest in peace."

In pictures: Jose Antonio Reyes' triumphant career after tragic news of former Arsenal forward's death

The forward scored eight goals for Arsene Wenger’s historic Arsenal side, which went 49 Premier League matches unbeaten.

That streak saw them lift the title in 2003-04, before continuing that run into the following season.

He scored 16 league goals for the Gunners during his three-year spell there between 2004-2007.

As well as lifting three consecutive Europa League titles with Sevilla, he was also part of the Atletico Madrid squad that won the competition in 2010 and 2012.

Atletico said in a tweet: “The Atletico de Madrid family is in mourning. Our former player Jose Antonio Reyes has passed away. You will forever be in our hearts. Rest in peace.”

Reyes spent four years at Atletico after joining the club in 2007. The previous season he had helped Real Madrid win LaLiga during a season-long loan from Arsenal.

Reyes also featured for both Espanyol and Benfica, among others.

His trophy-laden career saw him lift a domestic league title on three occasions in total while he also won the Europa League five times.

Former team-mate Freddie Ljungberg led the tributes and messages of condolence for Reyes, while football fans from around the globe paid their respects.

Reyes: ‘A genius’ and ‘exceptional human being’

Real Madrid captain Sergio Ramos, who like Reyes came up through the youth ranks at Sevilla and was a team-mate of his with Spain and Real, tweeted his shock at the death of his friend.

The 33-year-old wrote in Spanish: “Broken. Destroyed. I have no words. All the love to the family. We’ll always remember you, friend! RIP brother.”