A bad week for Bayern Munich got worse as Ciro Immobile's penalty handed Lazio the advantage in the first leg of their Champions League last-16 clash.

Immobile converted his spot-kick after Bayern defender Dayot Upamecano's clumsy challenge on Gustav Isaksen for which the France international was sent off with a straight red card.

Disciplined Lazio stifled the German side's attacks and Bayern were toothless throughout, failing to get a single effort on target in the match.

The Bavarians, favourites going into the game, were desperate to bounce back from Saturday's 3-0 Bundesliga loss to leaders Bayer Leverkusen which left them five points off the top.

They will return to Munich with more pressure piling on coach Thomas Tuchel and his team after their second straight defeat. They have failed score in their last two games.

Bayern started well and pressed the Italians high had created early chances for Joshua Kimmich and Harry Kane, who both narrowly missing the target.

The Italians, who had lost 6-2 on aggregate to Bayern at this stage three years ago, responded with a Luis Alberto missile that flew wide of Manuel Neuer's goal.

The tempo gradually dropped, Bayern struggled with the disciplined Italian back line and had to wait until the 40th minute to threaten again with Jamal Musiala firing over the bar from close range.

Lazio should have taken the lead two minutes after the restart when Isaksen only had Neuer to beat but the keeper stood his ground to block his shot.

The Dane earned a penalty when Immobile passed to Isaksen in the box and Upamecano arrived late and stepped on his ankle.

Immobile kept his cool and sent Neuer the wrong way to give his team the advantage going into the return leg in Munich on March 5

Additional reporting from Reuters