It is the French giants who come into the match-up in better European nick after downing Manchester City last time out, following an opening draw with Club Brugge.
The supposed Group A makeweights have been more than just a nuisance so far, having earlier beaten Leipzig to leave the Bundesliga club without a point ahead of perhaps their toughest game of the round.
A repeat of last season’s 2-1 win over PSG in Germany would be golden for the visitors at Parc des Princes, where they lost to a Neymar penalty in the reverse fixture.
An inconsistent start has left Leipzig eighth in the Bundesliga ahead of the game, with Les Parisiens cruising atop Ligue 1 following a late comeback win over Angers on the weekend.
Date, kick-off time and venue
PSG vs RB Leipzig is scheduled for an 8pm BST kick-off on Tuesday, October 19, 2021, at Parc des Princes in Paris.
Where to watch PSG vs RB Leipzig
TV channel: Tonight’s match will be televised on BT Sports 3.
Live stream: BT Sport subscribers will be able to watch the match online via the website or BT Sport app.
PSG vs RB Leipzig lineups and team news
PSG XI: Navas; Hakimi, Marquinhos, Kimpembe, Mendes; Herrera, Verratti, Gueye; Messi, Mbappe, Draxler.
Subs: Donnarumma, Danilo Pereira, Dagba, Wijnaldum, Kurzawa, Diallo, Kehrer, Ebimbe, Bitumazala, Letellier.
RB Leipzig XI: Gulacsi; Klostermann, Simakan, Orban, Mukiele; Haidara, Laimer; Nkunku, Adams, Angelino; Silva.
Subs: Poulsen, Forsberg, Szoboszlai, Moriba, Martinez, Gvardiol, Henrichs, Kampl.
PSG vs RB Leipzig prediction
Lionel Messi and Kylian Mbappe should have more than enough between them to fire PSG to victory without Neymar. Leipzig are slowly gathering momentum but this will be too much of an ask under the lights in Paris.
3-1 to PSG.
Head to head (h2h) history and results
PSG wins: 2
Leipzig wins: 1