A late Angelino goal gave the Bundesliga side a 1-0 aggregate lead last week.
While the young German club are yet to reach a European final or win a major trophy, Rangers’ history is steeped in silverware and a victory in this semi-final tie would set up a chance to win their first European honour since 1972.
An Old Firm draw with Celtic on the weekend means this is the Gers only significant chance of a title this season, while Leipzig lost to Borussia Monchengladbach to leave them outside the Bundesliga’s top four.
Here is everything you need to know ahead of the game...
Date, kick-off time and venue
Rangers vs RB Leipzig is scheduled for an 8pm BST kick-off today, Thursday, May 5, 2022.
Ibrox in Glasgow will host the match.
Where to watch Rangers vs RB Leipzig
TV channel: The match will be televised on BT Sport 2 and Ultimate, with coverage beginning at 7pm.
Live stream: BT Sport subscribers will be able to watch the match online via the BT Sport website or app.
Rangers vs RB Leipzig team news
Rangers XI: McGregor, Tavernier, Goldson, Lundstram, Bassey, Barisic, Jack, Aribo, Kamara, Wright, Kent.
Subs: Diallo, Davis, Ramsey, Sands, Balogun, McCrorie, Sakala, McLaughlin, Arfield, Lowry, King.
RB Leipzig: Gulacsi, Gvardiol, Orban, Klostermann, Henrichs, Laimer, Kampl, Angelino, Nkunku, Olmo, Poulsen.
Subs: Simakan, Forsberg, Tschauner, Adams, Szoboszlai, Mukiele, Halstenberg, Martinez, Andre Silva, Raebiger, Novoa.
Rangers vs RB Leipzig prediction
With a raucous Ibrox backing behind them and just a one-goal deficit, Rangers can be confident of striking early once more to take this one all the way.
A 1-0 Rangers win, Rangers to win on penalties.
Head to head (h2h) history and results
Last week’s first leg victory for Leipzig was the first meeting between the pair.