City’s impressive win over Chelsea on the weekend kept alive their hopes in English football’s other cup competition but it is in this tournament they have truly excelled under Pep Guardiola, lifting the trophy four times.
Southampton, meanwhile, also clocked a win in the FA Cup as Nathan Jones looks for a boost to their fight for survival.
Tonight’s game will be followed by the draw for the Carabao Cup semi-finals, which is also on Sky Sports.
Where to watch Southampton vs Man City
TV channel: In the UK, the match will be televised live on Sky Sports Football and Main Event, with coverage starting at 7.30pm GMT for an 8pm kick-off.
Live stream: Fans can also catch the game live online via the Sky go app.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.