With Richarlison and Dejan Kulusevski still sidelined through injury, Conte's assistant Cristian Stellini confirmed Friday that Conte will use the same front three that started the 4-0 win over Aston Villa, also including Bryan Gil.
Elsewhere, Emerson Royal and Ryan Sessegnon both come in at wing-back and Yves Bissouma returns to the midfield after serving a one-match ban against Palace. The Malian sits alongside Pape Matar Sarr.
Davinson Sanchez needs game-time and partners Japhet Tanganga on the right of the back three, with Ben Davies taking the other role.
Fraser Forster, who started the first game back at Brentford, is selected in goal ahead of Hugo Lloris.
Djed Spence is another player in desperate need of minutes but Spurs may not be risking cup-tying him, amid reports he could be sent on loan.
Starting Tottenham XI (3-4-3): Forster; Sanchez, Tanganga, Davies; Emerson, Bissouma, Sarr, Sessegnon; Son, Kane, Gil.