They have enjoyed some memorable tournaments recently, particularly at Euro 2016 when they reached the semi-finals, and are dreaming of more history.
The stage feels set for Gareth Bale to be a hero.
Here’s all you need to know about Wales...
Coach: Rob Page. Initially interim boss, he led Wales to the last-16 of Euro 2020 and then qualification for the World Cup before taking over from Ryan Giggs on a permanent basis.
Captain: Gareth Bale. Wales, golf, Madrid - in that order. Time for the 33-year-old to step up.
Star player: Bale. Still has a knack of scoring when it matters most, as shown by his dramatic late goal as LAFC won the MLS Cup this month.
One to watch: Brennan Johnson. The midfielder has shown flashes of his talent in the Premier League with Nottingham Forest but he has more to offer.
World ranking: 19th
Best thing about them: Their travelling fans.
Worst thing about them: England fans will never hear the end of it if they lose to them.
Their prospects in three words: Eyeing the knockouts.
Fixtures (all times GMT)
November 21 vs USA (7pm)
November 25 vs Iran (10am)
November 29 vs England (7pm)
Squad in full
Goalkeepers: Wayne Hennessey, Danny Ward, Adam Davies
Defenders: Ben Davies, Ben Cabango, Tom Lockyer, Joe Rodon, Chris Mephan, Ethan Ampadu, Chris Gunter, Neco Williams, Connor Roberts
Midfielders: Sorba Thomas, Joe Allen, Matthew Smith, Dylan Levitt, Harry Wilson, Joe Morrell, Jonny Williams, Aaron Ramsey, Rubin Colwill
Forwards: Gareth Bale, Kieffer Moore, Mark Harris, Brennan Johnson, Dan James