Smith took the WBA super-middleweight strap from George Groves in the final of last year’s World Boxing Super Series – a fight that turned out to be the Londoner’s last before retirement.
The 29-year-old Liverpudlian defends his belt for the first time against 35-year-old N’Dam, who holds a professional record of 37 wins (21 via knockout) and three defeats.
The Frenchman secured a surprise victory over Martin Murray in Manchester last December but has spent the majority of his professional career fighting at middleweight.
Smith’s title defence joins a promising card headlined by Joshua defending his IBF, WBA (Super) and WBO heavyweight titles against Ruiz on his US debut.
Katie Taylor will attempt to unify the women’s lightweight division when she takes on WBC champion Delfine Persoon.
Josh Kelly, one of Great Britain’s brightest welterweight prospects, will take on the experienced Ray Robinson, while Tommy Coyle will take on Chris Algieri for the WBO international super-lightweight strap.
Croydon’s Josh Buasti is also expected to be added to the card.