Harry Kane said Spurs are building "something special" with Mourinho off the back of Monday's 1-0 Premier League win at Burnley, and will want to keep that momentum going in Europe.
Date, time and venue
Antwerp vs Tottenham is scheduled for an 5.55pm GMT kick-off today (Thursday, October 29, 2020).
The match will be behind closed doors at Bosuilstadion in Antwerp, Belgium.
How to watch
TV channel: Antwerp vs Tottenham will be shown live on BT Sport 2, with coverage from 5:30pm.
Japhet Tanganga is out with a thigh injury, while Serge Aurier and Steven Bergwijn are fit to play after knocks.
With Spurs having already played plenty of games this season, the likes of Sergio Reguilon, Gareth Bale, Carlos Vinicius and Joe Hart should all start tonight.
However, Joe Rodon - like Paulo Gazzaniga and Danny Rose - is ineligible for the Europa League after making his Spurs debut late on at Burnley.
Tottenham predicted lineup (4-3-3): Hart; Aurier, Sanchez, Alderweireld, Reguilon; Winks, Lo Celso, Sissoko; Lamela, Bale, Vinicius
Prediction: Antwerp 0-2 Tottenham
While Antwerp won their opening game, Mourinho has plenty of options in his squad - and you'd expect a rotated Spurs XI to seal a victory in Belgium.
Head to head (h2h) history and results
These two sides are yet to meet in an official Uefa competition.
Betting odds and tips
Antwerp to win: 11/2
Tottenham to win: 8/15
Odds courtesy of Betfair Exchange. Click here to find out more.
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