The Gunners are taking on Swansea’s Under-23s at Meadow Park and the game is a chance for senior players to get minutes too.
Smith Rowe has been disrupted throughout pre-season due to a groin issue, but he took part in full training last week.
The attacking midfielder also managed to come off the bench on Saturday for the closing stages of Arsenal’s 4-2 win over Leicester in the Premier League.
Smith Rowe will now get further minutes on Wednesday night as he builds back to full fitness.
Vieira is also due to play for Arsenal’s Under-21s and he too has a had disrupted pre-season.
The Portugal international, who joined from Porto in the summer for around £34million, has had a foot issue but he also trained last week.