Monday's 2-0 win over West Brom is followed by the long journey to Belarus before welcoming Brighton to the Emirates Stadium on Sunday.
The midweek trip is the longest the Gunners will face in the Europa League group stage, with the October 19 visit to Red Star Belgrade coming in at 150 miles nearer.
Arsene Wenger will again shuffle his deck and told reporters on Monday that there is "room for us to be different" in regards to players afforded minutes ahead of an expected youthful group.
Scroll down for Standard Sport's comprehensive preview...
BATE Borisov host Arsenal at Borisov Stadium with kick-off scheduled for 6pm BST on Thursday, September 28.
TV and live online coverage
The match will be televised live on BT Sport 2 and BT Sport Showcase (available on Freeview) with coverage starting from 5.30pm. Alternatively, you can follow all the build-up and action from 5pm with Standard Sport’s London Football live blog.
Can't see the live blog? Click here for the desktop version.
Arsene Wenger will again rotate his squad heavily, with the likes of Jack Wilshere, Reiss Nelson and Ainsley Maitland-Niles coming in.
Arsenal host Brighton on Sunday in their third game in a six-day period, so unused substitutes against Koln like Jeff Reine-Adelaide and Chuba Akpom could also feature.
Mesut Ozil made a brief cameo off the bench in Monday's win over West Brom and could play a part after overcoming a knee injury.
Wenger told reporters on Monday: "We play in BATE Borisov on Thursday night and play Sunday morning at 12 o’clock here. So we look at the schedule over the weekend, we think there was some room for us to be different.
But we have to accept it and we want to go to Borisov with a team. I will go with a team of senior players and certainly with a young bench."
BATE Borisov starting XI: Scherbitshi; Rios, Gayduchik, Milunovic, Polyakov, Volodko; Dragun, Gordeychuk, Ivanic, Stasevich; Rodionov
Arsenal starting XI: Ospina; Holding, Mertesacker, Monreal; Nelson, Wilshere, Elneny, Maitland-Niles; Walcott, Willock, Giroud
Head to head
This is the first meeting between the two sides.
Betting odds (via betfair)
BATE Borisov to win: 9/2
Arsenal to win: 4/7
Click here to place a bet. Odds correct as of September 28 at 1pm.