All eyes are on the first team he picks - and intriguingly, Kai Havertz starts but Timo Werner is on the bench.
German coach Tuchel has been charged with the responsibility of turning the expensive duo’s form around - after Frank Lampard’s failure to get the best out the summer signings contributed to his sacking on Monday.
Werner’s last significant act under the former manager was to miss a late penalty against Luton.
Both he and Havertz have been dropped from key games in recent weeks as Chelsea’s form has plummeted.
However, Havertz starts along with compatriot Antonio Rudiger, while Mason Mount appears to be the first casualty of the Tuchel era with Lampard’s key midfielder relegated to the bench.
Christian Pulisic also loses his starting spot, with Callum Hudson-Odoi and Olivier Giroud playing in attack.
N’Golo Kante is close to recovery from a hamstring injury, but will have to wait until Burnley on Sunday to make his comeback.
It will be fascinating to see how Tuchel handles Kepa Arrizabalaga, who was going to be allowed to leave this month after being displaced by Edouard Mendy as No1.
Chelsea XI: Mendy, Azpilicueta, Rudiger, Thiago Silva, Chilwell, Jorginho, Kovacic, Ziyech, Havertz, Hudson-Odoi, Giroud
Subs: Arrizabalaga, Alonso, Abraham, Pulisic, Werner, Zouma, Mount, James, Emerson Palmieri