United go into the game at the Etihad Stadium three points ahead of their neighbours at the top of the table with three matches left in the season. If City win, they will go top of the table on goal difference.
"We know the exact situation we're in. We're in a better position than Manchester City," Ferguson told a news conference.
"We could come out with two good results whereas they only have one. Although you know my attitude and this club's attitude - we'll be trying to win."
Ferguson, seeking his 13th Premier League title with United, said he trusted his players to perform in such a high pressure game.
"I think there's enough experience. Patrice Evra, Rio Ferdinand, even Wayne Rooney has amassed a lot of football in his short time in the game," he said.
"Michael Carrick as well. There's enough experience in the camp to cope with this situation."
City humbled United 6-1 at Old Trafford in their first league meeting this season but the champions knocked their local rivals out of the FA Cup with a 3-2 victory at the Etihad Stadium.
"I think the previous encounters this season are irrelevant," Ferguson said.
"We've already met three times but the past is the past," added Ferguson referring to United's victory in the pre-season Community Shield match. "It doesn't matter. It's all down to Monday."
Ferguson tried to play down the inevitable hype surrounding the match, with City bidding to win the title for the first time since 1968.
"I suppose when the fixture came out at the beginning of the season all the roads pointed to this game," Ferguson said.
"It was inevitable maybe. But we are where we are and it doesn't matter what's happened before, who's dropped points or who hasn't dropped points. It really is all down to this game.
"It will be a fantastic atmosphere and I hope it lives up to the billing."
Ferguson said his players were still angry about conceding two late goals in their last match against Everton, allowing the visitors to snatch a dramatic 4-4 draw at Old Trafford.
"We're smarting from throwing that game away last week," he added.
"In the context of our history we almost expected it. We tend to make it hard for ourselves. Our supporters have been subjected to that sort of drama for years and years.
"God knows what their nerves are like now but, hopefully, we'll make amends on Monday," said Ferguson.