The Cottagers are enjoying a brilliant season under Marco Silva and will provide a tough examination for United, who are set to be without Cristiano Ronaldo in west London.
Ronaldo did not board the train that took his team-mates down to London on Saturday afternoon and, with talk of a January move away from Old Trafford, could have played his last game for United.
Here’s how to watch all the action live today...
Where to watch Fulham vs Man United
TV channel: In the UK, today’s game will be broadcast live on Sky Sports Main Event and Sky Sports Premier League, with coverage beginning at 4pm GMT ahead of a 4:30pm kick-off.
Live stream: Sky Sports subscribers will be able to watch live online via the Sky Go app.
LIVE coverage: Follow all the action with Standard Sport’s dedicated match blog. Nick Purewal will be providing expert analysis from Craven Cottage.